Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Research over the last decade has uncovered roles for bile acids (BAs) that extend beyond
their traditional functions in regulating lipid digestion and cholesterol metabolism. BAs are …

The causes of obstructive jaundice are varied, but it is most commonly due to
choledocholithiasis; benign strictures of the biliary tract; pancreaticobiliary malignancies; …

Abstract The large-conductance, Ca 2+-and voltage-activated K+(BK) channel is
ubiquitously expressed in mammalian tissues and displays diverse biophysical or …

Large conductance Ca2+-activated K+ (BKCa) channels are abundantly expressed in
vascular smooth muscle cells. Activation of BKCa channels leads to hyperpolarization of cell …

Cholesterol (CLR) is an essential component of eukaryotic plasma membranes. CLR
regulates the membrane physical state, microdomain formation and the activity of membrane …

Ion channels composed of pore-forming and auxiliary subunits control physiological
functions in virtually all cell types. A conventional view is that channels assemble with their …

Coded by a single gene (Slo1, KCM) and activated by depolarizing potentials and by a rise
in intracellular Ca2+ concentration, the large conductance voltage-and Ca2+-activated K+ …

Objective—Hypercholesterolemia and alcohol drinking constitute independent risk factors
for cerebrovascular disease. Alcohol constricts cerebral arteries in several species …