Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation

J Li, AA Green, H Yan, C Fan - Nature chemistry, 2017 - nature.com
Nucleic acids have attracted widespread attention due to the simplicity with which they can
be designed to form discrete structures and programmed to perform specific functions at the …

Framework-nucleic-acid-enabled biosensor development

F Yang, Q Li, L Wang, GJ Zhang, C Fan - ACS sensors, 2018 - ACS Publications
Nucleic acids have been actively exploited to develop various exquisite nanostructures due
to their unparalleled programmability. Especially, framework nucleic acids (FNAs) with …

Label-Free Electrochemical Sensing Platform for MicroRNA-21 Detection Using Thionine and Gold Nanoparticles Co-Functionalized MoS2 Nanosheet

D Zhu, W Liu, D Zhao, Q Hao, J Li… - … applied materials & …, 2017 - ACS Publications
Herein, we demonstrated a label-free and simple electrochemical sensing platform to detect
microRNA-21 (miR-21) with high sensitivity by using MoS2 nanosheet functionalized with …

DNA aptamer-based activatable probes for photoacoustic imaging in living mice

J Zhang, LP Smaga, NSR Satyavolu… - Journal of the …, 2017 - ACS Publications
DNA aptamers are a powerful class of molecules for sensing targets, but have been limited
when applied to imaging in living animals because most aptamer probes are fluorescence …

DNA nanotechnology-enabled interfacial engineering for biosensor development

D Ye, X Zuo, C Fan - Annual Review of Analytical Chemistry, 2018 - annualreviews.org
Biosensors represent biomimetic analytical tools for addressing increasing needs in medical
diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread …

Targeted imaging of brain tumors with a framework nucleic acid probe

T Tian, J Li, C Xie, Y Sun, H Lei, X Liu… - … applied materials & …, 2018 - ACS Publications
Development of agents for delivering drugs and imaging probes across the blood–brain
barrier (BBB) remains a major challenge. In this study, we designed a biocompatible …

Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction

D Ye, M Li, T Zhai, P Song, L Song, H Wang, X Mao… - Nature …, 2020 - nature.com
Circulating tumor cells (CTCs) enable noninvasive liquid biopsy and identification of cancer.
Various approaches exist for the capture and release of CTCs, including microfluidic …

Valency‐Controlled Framework Nucleic Acid Signal Amplifiers

Q Liu, Z Ge, X Mao, G Zhou, X Zuo, J Shen… - Angewandte …, 2018 - Wiley Online Library
Weak ligand–receptor recognition events are often amplified by recruiting multiple
regulatory biomolecules to the action site in biological systems. However, signal …

In Situ Spatial Complementation of Aptamer‐Mediated Recognition Enables Live‐Cell Imaging of Native RNA Transcripts in Real Time

Z Wang, Y Luo, X Xie, X Hu, H Song, Y Zhao… - Angewandte …, 2018 - Wiley Online Library
Direct cellular imaging of the localization and dynamics of biomolecules helps to understand
their function and reveals novel mechanisms at the single‐cell resolution. In contrast to …

Biomimetic DNA nanotubes: nanoscale channel design and applications

X Liu, Y Zhao, P Liu, L Wang, J Lin… - Angewandte Chemie …, 2019 - Wiley Online Library
Biomacromolecular nanotubes play important physiological roles in transmembrane
ion/molecule channeling, intracellular transport, and inter‐cellular communications. While …