Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …

Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

Our goal was to generate functionalized 3D-printed scaffolds for bone regeneration using
silk-hydroxyapatite bone cements and osteoinductive, proangiogenic and neurotrophic …

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity,
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …

Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …