Autophagy is a complex process involved in several cell activities, including tissue growth,
differentiation, metabolic modulation, and cancer development. In prostate cancer …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Autophagy is a process of self-degradation that plays an important role in removing
damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions …

The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1) plays a role in the
progression of various tumors, emerging as a potential therapeutic target. This study aimed …

Circadian rhythms are physical, behavioral and environmental cycles that respond primarily
to light and dark, with a period of time of approximately 24 h. The most essential …

Conventional chemotherapeutic agents for colorectal cancer (CRC) cause systemic side
effects and eventually become less efficacious owing to the development of drug resistance …

Although the treatment of cancer has made great strides in clinical practice, its high
morbidity and fatality rates remain a major threat to human health. Multidrug resistance …

The drug development process, especially of antineoplastic agents, has become
increasingly costly and ineffective. Drug repurposing and drug combination are alternatives …

The phytochemical sulforaphane (SFN) has been studied for its potential anti-obesity effect,
but neither its molecular targets nor its interaction with the antimalarial drug chloroquine …

Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ), the compounds with
recognized ability to suppress autophagy, have been tested in experimental works and in …