Stress adaptation in a pathogenic fungus
AJP Brown, S Budge, D Kaloriti… - Journal of …, 2014 - journals.biologists.com
Candida albicans is a major fungal pathogen of humans. This yeast is carried by many
individuals as a harmless commensal, but when immune defences are perturbed it causes …
individuals as a harmless commensal, but when immune defences are perturbed it causes …
Metabolism in fungal pathogenesis
Fungal pathogens must assimilate local nutrients to establish an infection in their
mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms …
mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms …
Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast
Thermal adaptation is essential in all organisms. In yeasts, the heat shock response is
commanded by the heat shock transcription factor Hsf1. Here we have integrated unbiased …
commanded by the heat shock transcription factor Hsf1. Here we have integrated unbiased …
Post-translational modifications drive success and failure of fungal–host interactions
C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …
The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans
Microbes must assimilate carbon to grow and colonize their niches. Transcript profiling has
suggested that Candida albicans, a major pathogen of humans, regulates its carbon …
suggested that Candida albicans, a major pathogen of humans, regulates its carbon …
More than just cleaning: ubiquitin-mediated proteolysis in fungal pathogenesis
C Cao, C Xue - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of
cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome …
cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome …
Posttranslational modifications of proteins in the pathobiology of medically relevant fungi
Posttranslational modifications of proteins drive a wide variety of cellular processes in
eukaryotes, regulating cell growth and division as well as adaptive and developmental …
eukaryotes, regulating cell growth and division as well as adaptive and developmental …
Global Transcriptome Profile of Cryptococcus neoformans during Exposure to Hydrogen Peroxide Induced Oxidative Stress
The ability of the opportunistic fungal pathogen Cryptococcus neoformans to resist oxidative
stress is one of its most important virulence related traits. To cope with the deleterious effect …
stress is one of its most important virulence related traits. To cope with the deleterious effect …
Genomic and transcriptomic analyses of the tangerine pathotype of Alternaria alternata in response to oxidative stress
The tangerine pathotype of Alternaria alternata produces the A. citri toxin (ACT) and is the
causal agent of citrus brown spot that results in significant yield losses worldwide. Both the …
causal agent of citrus brown spot that results in significant yield losses worldwide. Both the …
Elevated catalase expression in a fungal pathogen is a double-edged sword of iron
A Pradhan, C Herrero-de-Dios, R Belmonte… - PLoS …, 2017 - journals.plos.org
Most fungal pathogens of humans display robust protective oxidative stress responses that
contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen …
contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen …