Considerable progress has been made in the field of extrusion-based bioprinting (EBB) to
produce constructs able to recapitulate the functionality of tissues, and it remains the most …

The use of engineered cells, tissues, and organs has the opportunity to change the way
injuries and diseases are treated. Commercialization of these groundbreaking technologies …

Non-destructive, inline quality monitoring techniques that can overcome the limitations of
traditional, offline assays are essential to support the scale-up production of tissue …

Background Knee osteoarthritis (OA) is a common, chronic, progressive and degenerative
disease which affects patients' quality of life and may cause disability and social isolation …

Biofabrication processes can affect biological quality attributes of encapsulated cells within
constructs. Currently, assessment of the fabricated constructs is performed offline by …

Tissue engineered hyaline cartilage is plagued by poor mechanical properties largely due to
inadequate type II collagen expression. Of note, commonly used defined chondrogenic …

Mesenchymal stem cells (MSCs) are promising cells to treat cartilage defects due to their
chondrogenic differentiation potential. However, an inflammatory environment during …

Paracrine signaling is challenging to study in vitro, as conventional culture tools dilute
soluble factors and offer little to no spatiotemporal control over signaling. Microfluidic chips …

Background: Articular cartilage repair using implantable photocrosslinkable hydrogels laden
with chondrogenic cells, represents a promising in situ cartilage engineering approach for …

Cell aggregates hold significant therapeutic promise for in vitro cell analysis, ex vivo tissue
models, and in vivo cell therapy and tissue engineering. Traditional methods of making cell …