The monophyletic group of embryophytes (land plants) stands out among photosynthetic
eukaryotes: they are the sole constituents of the macroscopic flora on land. In their entirety …

The alarming rise in drug-resistant clinical cases of tuberculosis (TB) has necessitated the
rapid development of newer chemotherapeutic agents with novel mechanisms of action. The …

Tetracyclines are a class of antibiotics that exhibited potent activity against a wide range of
Gram-positive and Gram-negative bacteria, yet only five members were isolated from …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are
sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard …

The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this
bacterium to access iron when it is in an infected host. Due to this essential function, there is …

We report on the virtual screening, synthesis, and biological evaluation of new furan
derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor …

Over a decade ago, the analysis of the complete sequence of the genome of the human
pathogen Mycobacterium tuberculosis revealed an unexpectedly high number of open …

SF2575 1 is a tetracycline polyketide produced by Streptomyces sp. SF2575 and displays
exceptionally potent anticancer activity toward a broad range of cancer cell lines. The …

Chorismate and isochorismate represent an important branching point connecting primary
and secondary metabolism in bacteria, fungi, archaea and plants. Chorismate-and …