Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

[HTML][HTML] Dynamic control in metabolic engineering: Theories, tools, and applications

CJ Hartline, AC Schmitz, Y Han, F Zhang - Metabolic engineering, 2021 - Elsevier
Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Metabolic engineering for the production of dicarboxylic acids and diamines

TU Chae, JH Ahn, YS Ko, JW Kim, JA Lee, EH Lee… - Metabolic …, 2020 - Elsevier
Microbial production of chemicals and materials from renewable carbon sources is
becoming increasingly important to help establish sustainable chemical industry. In this …

Microbial synthesis of medium-chain chemicals from renewables

S Sarria, NS Kruyer, P Peralta-Yahya - Nature Biotechnology, 2017 - nature.com
Abstract Linear, medium-chain (C8–C12) hydrocarbons are important components of fuels
as well as commodity and specialty chemicals. As industrial microbes do not contain …

Recent advances in the production of platform chemicals using metabolically engineered microorganisms

JY Kim, YJ Ahn, JA Lee, SY Lee - Current Opinion in Green and …, 2023 - Elsevier
Due to the intensifying climate crisis and other environmental problems caused by our heavy
dependence on fossil resources, there has been much effort to establish biorefinery …

Short-chain ketone production by engineered polyketide synthases in Streptomyces albus

S Yuzawa, M Mirsiaghi, R Jocic, T Fujii… - Nature …, 2018 - nature.com
Microbial production of fuels and commodity chemicals has been performed primarily using
natural or slightly modified enzymes, which inherently limits the types of molecules that can …

Multilayer engineering of enzyme cascade catalysis for one-pot preparation of nylon monomers from renewable fatty acids

TH Kim, SH Kang, JE Han, EJ Seo, EY Jeon… - ACS …, 2020 - ACS Publications
Enzyme cascade catalysis has critical problems in obtaining the high concentrations of
products, such as the low stabilities and activities of biocatalysts and the inhibition by …

Engineering diverse fatty acid compositions of phospholipids in Escherichia coli

W Bai, WE Anthony, CJ Hartline, S Wang, B Wang… - Metabolic …, 2022 - Elsevier
Bacterial fatty acids (FAs) are an essential component of the cellular membrane and are an
important source of renewable chemicals as they can be converted to fatty alcohols, esters …

Reprogramming Escherichia coli Metabolism for Bioplastics Synthesis from Waste Cooking Oil

Y Li, Z Cheng, C Zhao, C Gao, W Song, L Liu… - ACS Synthetic …, 2021 - ACS Publications
The recycle and reutilization of food wastes is a promising alternative for supporting and
facilitating circular economy. However, engineering industrially relevant model organisms to …

De novo biosynthesis of nylon 12 monomer ω-aminododecanoic acid

J Ge, T Wang, H Yu, L Ye - Nature Communications, 2025 - nature.com
Nylon 12 is valued for its exceptional properties and diverse industrial applications.
Traditional chemical synthesis of nylon 12 faces significant technical challenges and …