The management and treatment of bone cancer pain (BCP) remain significant clinical
challenges, imposing substantial economic burdens on patients and society. Extensive …

Chronic pain is a prevalent condition with a multifaceted pathogenesis, where epigenetic
modifications, particularly DNA methylation, might play an important role. This review delves …

Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent
diseases, and current treatments rely primarily on opioids, which have significant side …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

Simple Summary Cancer stands as a major public health concern worldwide, and a
significant proportion of survivors are affected by recurrent and usually unrelieved cancer …

Chronic temporomandibular joint (TMJ) pain profoundly affects patients' quality of life.
Trigeminal tumor necrosis factor-α (TNFα) plays a pivotal role in mediating TMJ pain in mice …

Bone is a common site of advanced cancer metastasis, second only to the lungs and liver.
Cancer-induced bone pain (CIBP) is a persistent and intense pain that is caused by a …