Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

Cysteine proteases continue to provide validated targets for treatment of human diseases. In
neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

We have designed a highly specific inhibitor of calpain by mimicking a natural protein–
protein interaction between calpain and its endogenous inhibitor calpastatin. To enable this …

Calpains are a family of complex multi-domain intracellular enzymes that share a calcium-
dependent cysteine protease core. These are not degradative enzymes, but instead carry …

Many factors contribute to nervous system dysfunction and failure to regenerate after injury
or disease. Here, we describe a previously unrecognized mechanism for nervous system …

Proteases are enzymes that cleave peptide bonds in protein substrates. This process can be
important for regulated turnover of a target protein but it can also produce protein fragments …

The Ca2+-dependent cysteine proteases, calpains, regulate cell migration, cell death,
insulin secretion, synaptic function and muscle homeostasis. Their endogenous inhibitor …

Kinases play central roles in signaling cascades, relaying information from the outside to the
inside of mammalian cells. De novo designed protein switches capable of interfacing with …

This review was written in memory of our late friend, Dr. Hiroyuki Sorimachi, who, following
the steps of his mentor Koichi Suzuki, a pioneer in calpain research, has made tremendous …