The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

Tissue engineering is a newly emerging biomedical technology, which aids and increases
the repair and regeneration of deficient and injured tissues. It employs the principles from …

Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …

As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

Invasion of placental trophoblasts into uterine tissue and vessels is an essential process of
human pregnancy and fetal development. Due to their remarkable plasticity invasive …

The ability of stem cells to differentiate into multiple cell lineages has ushered in exciting
possibilities for stem cell based therapies that would be used to regenerate and repair …

The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

The first definitive cell fate decision in development occurs at the blastocyst stage with
establishment of the trophoblast and embryonic cell lineages. In the mouse, lineage …

Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …

BACKGROUND Investigating the mechanisms of human primordial germ cell (PGC) and
gamete development are important for understanding the causes of infertility and effects of …