Factors affecting the performance of HRP2-based malaria rapid diagnostic tests
The recent COVID-19 pandemic has profoundly impacted global malaria elimination
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …
Potential opportunities and challenges of deploying next generation sequencing and CRISPR-Cas systems to support diagnostics and surveillance towards malaria …
Recent developments in molecular biology and genomics have revolutionized biology and
medicine mainly in the developed world. The application of next generation sequencing …
medicine mainly in the developed world. The application of next generation sequencing …
Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021
Plasmodium falciparum with the histidine rich protein 2 gene (pfhrp2) deleted from its
genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The …
genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The …
[HTML][HTML] Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions from persons with symptomatic malaria infection in Ethiopia, Kenya, Madagascar, and Rwanda
E Rogier, JN McCaffery, D Nace, SS Svigel… - Emerging Infectious …, 2022 - ncbi.nlm.nih.gov
Abstract Histidine-rich protein 2 (HRP2)–based rapid diagnostic tests detect Plasmodium
falciparum malaria and are used throughout sub-Saharan Africa. However, deletions in the …
falciparum malaria and are used throughout sub-Saharan Africa. However, deletions in the …
[HTML][HTML] Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions and relatedness to other global isolates, Djibouti, 2019–2020
E Rogier, JN McCaffery, MA Mohamed… - Emerging Infectious …, 2022 - ncbi.nlm.nih.gov
Deletions of pfhrp2 and paralogue pfhrp3 (pfhrp2/3) genes threaten Plasmodium falciparum
diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria …
diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria …
Prevalence of asymptomatic malaria, submicroscopic parasitaemia and anaemia in Korogwe District, north-eastern Tanzania
Background Asymptomatic malaria infections largely remain undetected and act as a
reservoir for continuous transmission. The study assessed the prevalence of submicroscopic …
reservoir for continuous transmission. The study assessed the prevalence of submicroscopic …
Prescription patterns and compliance with World Health Organization recommendations for the management of uncomplicated and severe malaria: a prospective, real …
Background This study aimed to evaluate the gap between guidelines and local clinical
practice for diagnosis and treatment of uncomplicated and severe malaria, the patient …
practice for diagnosis and treatment of uncomplicated and severe malaria, the patient …
Rapid diagnostic tests for malaria diagnosis in Cameroon: Impact of histidine rich protein 2/3 deletions and lactate dehydrogenase gene polymorphism
RRD Nana, NL Ngum, V Makoge… - … and Infectious Disease, 2024 - Elsevier
Malaria rapid diagnostic tests (mRDT) play a vital role in malaria control in endemic areas. In
this study, histidine-rich protein (hrp) and lactate dehydrogenase (ldh) genes were …
this study, histidine-rich protein (hrp) and lactate dehydrogenase (ldh) genes were …
Laboratory detection of malaria antigens: a strong tool for malaria research, diagnosis, and epidemiology
M Plucinski, M Aidoo, E Rogier - Clinical Microbiology Reviews, 2021 - Am Soc Microbiol
The identification and characterization of proteins produced during human infection with
Plasmodium spp. have guided the malaria community in research, diagnosis, epidemiology …
Plasmodium spp. have guided the malaria community in research, diagnosis, epidemiology …
Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients in the DRC enrolled from 2017 to 2018
JN McCaffery, D Nace, C Herman, B Singh… - Scientific Reports, 2021 - nature.com
Rapid diagnostic tests (RDTs) detecting histidine-rich protein 2 (HRP2) and HRP3 are
widely used throughout sub-Saharan Africa (SSA) to diagnose Plasmodium falciparum …
widely used throughout sub-Saharan Africa (SSA) to diagnose Plasmodium falciparum …