TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Alzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor
expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an …

Parkinson's disease (PD) is one of most common neurodegenerative disorders caused by a
combination of environmental and genetic risk factors. Currently, numerous population …

Background Α number of genetic variants are considered to confer susceptibility to
Parkinson's disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been …

Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial
receptor exclusively expressed in the central nervous system (CNS). It contributes to …

Background Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial
surface receptor that mediates the degradation disorder of amyloid β (Aβ) in Alzheimer's …

Triggering receptor expressed on myeloid cells 2 (TREM-2), a glycosylated receptor
belonging to the immunoglobin superfamily and especially expressed in the myeloid cell …

Recently, several studies have investigated the association between the rare mutation of
triggering receptor expressed on myeloid cells 2 (TREM2) gene (rs75932628-T) and the risk …

Neurodegenerative diseases are manifested by a progressive death of neural cells,
resulting in the deterioration of central nervous system (CNS) functions, ultimately leading to …

Leukoaraiosis (LA) appears as white matter hyperintensities on T2-weighted brain magnetic
resonance imaging scans. Age and hypertension are considered the primary risk factors for …