Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer has a high
metastatic potential. Monoclonal antibodies (mAbs) that target HER2, such as trastuzumab …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer.
Transforming growth factor beta (TGF-β) is highly expressed in the liver tumor …

Over recent years, the use of immune checkpoint inhibitors (ICI) has progressed to first and
second-line treatments in several cancer types, transforming patient outcomes. While these …

Over the past decade, immune checkpoint inhibitor (ICI) therapy has been established as
the standard of care for many types of cancer, but the strategies employed have continued to …

Enhancing natural killer (NK) cell-based innate immunity has become a promising strategy
for immunotherapy against hard-to-cure solid cancers. Monoclonal antibody (mAb) therapy …

Lung cancer is the leading cause of cancer-related death worldwide. Although natural killer
(NK) cells are garnering interest as a potential anticancer therapy because they selectively …

Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using
germline-encoded receptors. These receptors are stochastically co-expressed, and their …

An apparent paradox exists between the evidence for spontaneous systemic T cell-mediated
anti-tumor immune responses in cancer patients, observed particularly in their bone marrow …

Abstract Cancer-associated fibroblasts (CAFs), which are the most frequent stromal cells in
the tumor microenvironment (TME), play a key role in the metastasis of tumor cells …