From input to output: the Lap/c-di-GMP biofilm regulatory circuit
Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of
bacterial biofilms has been the subject of study in many organisms. Over the last two …
bacterial biofilms has been the subject of study in many organisms. Over the last two …
Gene regulation and transcriptomics
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …
BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals
AA Grassmann, R Tokarz, C Golino… - The Journal of …, 2023 - Am Soc Clin Investig
The RNA polymerase alternative σ factor RpoS in Borrelia burgdorferi (Bb), the Lyme
disease pathogen, is responsible for programmatic-positive and-negative gene regulation …
disease pathogen, is responsible for programmatic-positive and-negative gene regulation …
Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems
Abstract Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in
many bacterial species, where it functions as a nucleotide-based secondary messenger and …
many bacterial species, where it functions as a nucleotide-based secondary messenger and …
Borreliella burgdorferi antimicrobial-tolerant persistence in Lyme disease and posttreatment Lyme disease syndromes
The annual incidence of Lyme disease, caused by tick-transmitted Borreliella burgdorferi, is
estimated to be at least 476,000 cases in the United States and many more worldwide. Ten …
estimated to be at least 476,000 cases in the United States and many more worldwide. Ten …
Borrelia burgdorferi PlzA is a cyclic‐di‐GMP dependent DNA and RNA binding protein
N Jusufovic, AC Krusenstjerna… - Molecular …, 2024 - Wiley Online Library
The PilZ domain‐containing protein, PlzA, is the only known cyclic di‐GMP binding protein
encoded by all Lyme disease spirochetes. PlzA has been implicated in the regulation of …
encoded by all Lyme disease spirochetes. PlzA has been implicated in the regulation of …
Interactions between ticks and lyme disease spirochetes
Borrelia burgdorferi sensu lato causes Lyme borreliosis in a variety of animals and humans.
These atypical bacterial pathogens are maintained in a complex enzootic life cycle that …
These atypical bacterial pathogens are maintained in a complex enzootic life cycle that …
The consistent tick-vertebrate infectious cycle of the Lyme disease spirochete enables Borrelia burgdorferi to control protein expression by monitoring its physiological …
B Stevenson, AC Krusenstjerna… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT The Lyme disease spirochete, Borrelia burgdorferi, persists in nature by
alternatingly cycling between ticks and vertebrates. During each stage of the infectious …
alternatingly cycling between ticks and vertebrates. During each stage of the infectious …
BadR directly represses the expression of the glycerol utilization operon in the Lyme disease pathogen
Glycerol utilization as a carbohydrate source by Borreliella burgdorferi, the Lyme disease
spirochete, is critical for its successful colonization and persistence in the tick vector. The …
spirochete, is critical for its successful colonization and persistence in the tick vector. The …
PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi
AM Groshong, AA Grassmann, A Luthra… - PLoS …, 2021 - journals.plos.org
In this study, we examined the relationship between c-di-GMP and its only known effector
protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the …
protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the …