Ongoing diphtheria outbreak in Yemen: a cross-sectional and genomic epidemiology study

E Badell, A Alharazi, A Criscuolo, KAA Almoayed… - The Lancet …, 2021 - thelancet.com
Background An outbreak of diphtheria, declared in Yemen in October, 2017, is ongoing. We
did a cross-sectional study to investigate the epidemiological, clinical, and microbiological …

Whole genome sequencing for surveillance of diphtheria in low incidence settings

HMB Seth-Smith, A Egli - Frontiers in public health, 2019 - frontiersin.org
Corynebacterium diphtheriae (C. diphtheriae) is a relatively rare pathogen in most Western
countries. While toxin producing strains can cause pharyngeal diphtheria with potentially …

CRISPRStudio: a user-friendly software for rapid CRISPR array visualization

MB Dion, SJ Labrie, SA Shah, S Moineau - Viruses, 2018 - mdpi.com
The CRISPR-Cas system biologically serves as an adaptive defense mechanism against
phages. However, there is growing interest in exploiting the hypervariable nature of the …

Detection and Characterization of Diphtheria Toxin Gene-Bearing Corynebacterium Species through a New Real-Time PCR Assay

MM Williams, JL Waller, JS Aneke… - Journal of Clinical …, 2020 - Am Soc Microbiol
Respiratory diphtheria, characterized by a firmly adherent pseudomembrane, is caused by
toxin-producing strains of Corynebacterium diphtheriae, with similar illness produced …

Distinct genomic features characterize two clades of Corynebacterium diphtheriae: proposal of Corynebacterium diphtheriae Subsp. diphtheriae Subsp. Nov. and …

F Tagini, T Pillonel, A Croxatto, C Bertelli… - Frontiers in …, 2018 - frontiersin.org
Corynebacterium diphtheriae is the etiological agent of diphtheria, a disease caused by the
presence of the diphtheria toxin. However, an increasing number of records report non …

A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence

M Hennart, C Crestani, S Bridel… - Peer Community …, 2023 - peercommunityjournal.org
Background: Diphtheria, caused by Corynebacterium diphtheriae, reemerges in Europe
since 2022. Genomic sequencing can inform on transmission routes and genotypes of …

Genomic Epidemiology and Strain Taxonomy of Corynebacterium diphtheriae

J Guglielmini, M Hennart, E Badell… - Journal of Clinical …, 2021 - Am Soc Microbiol
Corynebacterium diphtheriae is highly transmissible and can cause large diphtheria
outbreaks where vaccination coverage is insufficient. Sporadic cases or small clusters are …

Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018

A Berger, A Dangel, T Schober… - …, 2019 - eurosurveillance.org
In September 2018, a child who had returned from Somalia to Germany presented with
cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child's …

Molecular diagnostics in South Africa and challenges in the establishment of a molecular laboratory in developing countries

A Singh-Moodley, H Ismail, O Perovic - The Journal of Infection in …, 2020 - jidc.org
The laboratory plays a significant role in public health surveillance, outbreak investigation
and infection prevention and control strategies. Microbiology laboratories are moving …

Whole-genome sequencing of Corynebacterium diphtheriae isolates recovered from an inner-city population demonstrates the predominance of a single molecular …

SD Chorlton, G Ritchie, T Lawson… - Journal of Clinical …, 2020 - Am Soc Microbiol
In some parts of the world, Corynebacterium diphtheriae has reemerged as a pathogen,
especially as a cause of infections among impoverished and marginalized populations. We …