Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided
into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of …

Neurofilaments (NFs) are multisubunit, neuron-specific intermediate filaments consisting of a
10-nm diameter filament “core” surrounded by a layer of long intrinsically disordered protein …

The intermediate filament protein vimentin performs an essential role in cytoskeletal
interplay and dynamics, mechanosensing and cellular stress responses. In pathology …

Intermediate filaments (IFs) are integral to the cell cytoskeleton, supporting cellular
mechanical stability. Unlike other cytoskeletal components, the detailed structure of …

The coordination of cytoskeletal proteins shapes cell architectures and functions. Age-
related changes in cellular mechanical properties have been linked to decreased cellular …

The epithelial–mesenchymal transition (EMT) program is critical to metastatic cancer
progression. EMT results in the expression of mesenchymal proteins and enhances …

Nuclear pore complexes (NPCs) are nuclear gateways which regulate the transit of
molecules larger than 40kDa through a Ran-dependent transport. The somatic human NPC …

Cryogenic electron microscopy (cryo-EM) and cryogenic electron tomography allow
determination of structures of biological macromolecules in their native state in solution at …

The intricate assembly process of vimentin intermediate filaments (IFs), key components of
the eukaryotic cytoskeleton, has yet to be elucidated. In this work, we investigated the …

Cryogenic-electron tomography (cryo-ET) has provided an unprecedented glimpse into the
nanoscale architecture of cells by combining cryogenic preservation of biological structures …