Cancer survivorship: an integral part of Europe's research agenda
P Lagergren, A Schandl, NK Aaronson… - Molecular …, 2019 - Wiley Online Library
Cancer survivorship has traditionally received little prioritisation and attention. For a long
time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is …
time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is …
[HTML][HTML] Defining the role of real-world data in cancer clinical research: The position of the European Organisation for Research and Treatment of Cancer
R Saesen, M Van Hemelrijck, J Bogaerts… - European Journal of …, 2023 - Elsevier
The emergence of the precision medicine paradigm in oncology has led to increasing
interest in the integration of real-world data (RWD) into cancer clinical research. As sources …
interest in the integration of real-world data (RWD) into cancer clinical research. As sources …
Analysis of the characteristics and the degree of pragmatism exhibited by pragmatic-labelled trials of antineoplastic treatments
R Saesen, K Depreytere, K Krupianskaya… - BMC Medical Research …, 2023 - Springer
Abstract Background Pragmatic clinical trials (PCTs) are designed to reflect how an
investigational treatment would be applied in clinical practice. As such, unlike their …
investigational treatment would be applied in clinical practice. As such, unlike their …
[HTML][HTML] How do cancer clinicians perceive real-world data and the evidence derived therefrom? Findings from an international survey of the European Organisation …
R Saesen, G Kantidakis, A Marinus… - Frontiers in …, 2022 - frontiersin.org
Background: The role of real-world evidence (RWE) in the development of anticancer
therapies has been gradually growing over time. Regulators, payers and health technology …
therapies has been gradually growing over time. Regulators, payers and health technology …
[HTML][HTML] Are global health systems ready for transformative therapies?
E Faulkner, DS Spinner, M Ringo, M Carroll - Value in Health, 2019 - Elsevier
Background We have seen significant advancement in a range of health technologies, some
with transformative or curative potential. Nevertheless, it is often unclear how global health …
with transformative or curative potential. Nevertheless, it is often unclear how global health …
Drug development for major chronic health conditions—aligning with growing public health needs: Proceedings from a multistakeholder think tank
KA Krychtiuk, TLG Andersson, U Bodesheim… - American Heart …, 2024 - Elsevier
The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases
due to more predictable development pathways and financial incentives. In contrast, drug …
due to more predictable development pathways and financial incentives. In contrast, drug …
[HTML][HTML] Real-world data in oncology: a questionnaire-based analysis of the academic research landscape examining the policies and experiences of the cancer …
R Saesen, D Lacombe, I Huys - ESMO open, 2023 - Elsevier
Background Real-world data (RWD) have quickly emerged as an important source of
information to address uncertainties about new treatments, including novel anticancer …
information to address uncertainties about new treatments, including novel anticancer …
[HTML][HTML] Design, organisation and impact of treatment optimisation studies in breast, lung and colorectal cancer: The experience of the European Organisation for …
R Saesen, D Lacombe, I Huys - European Journal of Cancer, 2021 - Elsevier
Abstract Background Treatment optimisation studies (TOSs) are clinical trials which aim to
tackle research questions that are often left unaddressed within the current drug …
tackle research questions that are often left unaddressed within the current drug …
Views of European drug development stakeholders on treatment optimization and its potential for use in decision-making
R Saesen, S Lejeune, G Quaglio… - Frontiers in …, 2020 - frontiersin.org
Background The current drug development paradigm has been criticized for being too drug-
centered and for not adequately focusing on the patients who will eventually be …
centered and for not adequately focusing on the patients who will eventually be …
[HTML][HTML] Breast Cancer: global quality care optimizing care delivery with existing financial and personnel resources
Our vision about breast cancer quality care within a global health framework was recently
published by Oxford University Press. The aim of our work was to reflect on the potential to …
published by Oxford University Press. The aim of our work was to reflect on the potential to …