Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …

The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …

Natural killer (NK) cells are potent immune effector cells that can respond to infection and
cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant …

Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …

Immune cells, including natural killer (NK) cells, recognize transformed cells and eliminate
them in a process termed immunosurveillance. It is thought that tumor cells evade …

Abstract The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting
the host from infections and cancer. By recognizing ligands induced on infected or tumor …

A growing body of research is addressing how pathways that are dysregulated during
tumorigenesis are linked to innate immune responses, which can contribute to immune …

Protection against cellular stress from various sources, such as nutritional, physical,
pathogenic, or oncogenic, results in the induction of both intrinsic and extrinsic cellular …

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing
nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and …