Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Epidemiological data from the Center of Disease Control (CDC) and the World Health
Organization (WHO) statistics in 2017 show that 10.0 million people around the world …

While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …

Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …

Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed,
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

Tuberculosis is primarily a respiratory disease that is caused by Mycobacterium
tuberculosis. M. tuberculosis can persist and replicate in macrophages in vivo, usually in …

The human body frequently encounters harmful bacterial pathogens and employs immune
defense mechanisms designed to counteract such pathogenic assault. In the adaptive …

Peptides presented by HLA-E, a molecule with very limited polymorphism, represent
attractive targets for T cell receptor (TCR)-based immunotherapies to circumvent the …