Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Rho GTPases are molecular switches that regulate many essential cellular processes,
including actin dynamics, gene transcription, cell-cycle progression and cell adhesion …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

Myo-inositol is a versatile compound that generates diversified derivatives upon
phosphorylation by lipid-dependent and-independent pathways. Phosphatidylinositols form …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …

Abstract Synthesis of phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2], a signaling
phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI (4) …

Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly
and disassembly of the actin cytoskeleton in response to extracellular signals. During the …