Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

With the success of immune checkpoint inhibitors (ICIs), significant progress has been made
in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the …

Immunotherapy is revolutionizing the clinical management of multiple tumors. However, only
a fraction of patients with cancer responds to immunotherapy, and currently available …

Metastatic disease is the leading cause of cancer-related deaths and involves critical
interactions between tumor cells and the microenvironment. Hypoxia is a potent …

Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …

Tumors use several strategies to evade the host immune response, including creation of an
immune-suppressive and hostile tumor environment. Tissue hypoxia due to inadequate …

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism
and cope with microenvironmental perturbations. Moreover, autophagy connects cellular …

The tumor microenvironment is a complex system, playing an important role in tumor
development and progression. Besides cellular stromal components, extracellular matrix …