Background: While persistent opioid use after surgery has been the subject of a large
number of studies, it is unknown how much variability in the definition of persistent use …

The drug-induced, reversible coma of anaesthesia requires three clinical outcomes:
unconsciousness, immobility, and the control of autonomic nervous system (ANS) responses …

While US opioid prescribing has decreased 38% in the past decade, opioid deaths have
increased 300%. This opioid paradox is poorly recognized. Current approaches to opioid …

Background Opioids are overprescribed after surgical procedures, leading to dependence
and diversion into the community. This can be mitigated by evidence-based prescribing …

Abstract Background and Aims Opioid overdose is a public health emergency in the United
States. In an attempt to reduce potentially inappropriate opioid prescribing, many US states …

Objective: The aim of this study was to determine preoperative patient characteristics
associated with postoperative outpatient opioid use and assess the frequency of …

Importance Since the Centers for Disease Control and Prevention published opioid
prescribing guidelines in March 2016, 31 states have implemented legislation to restrict the …

Recent clinical guidelines have emphasized non-opioid treatments in lieu of prescription
opioids for chronic non-cancer pain, exempting cancer patients from these …

The opioid overdose epidemic combined with the need to reduce the burden of acute pain
poses a public health challenge. To address how evidence-based clinical practice …

By numerous measures, opioid-related harm in the United States has been increasing over
the past 2 decades. Rates of opioid misuse and overdose have reached new highs in recent …