Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …

Chimaeras are both monsters of the ancient imagination and a long-established research
tool. Recent advances, particularly those dealing with the identification and generation of …

Heterologous organ transplantation is an effective way of replacing organ function but is
limited by severe organ shortage. Although generating human organs in other large …

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

Embryonic pluripotency can be recapitulated in vitro by a spectrum of pluripotent stem cell
states stabilized with different culture conditions. Their distinct spatiotemporal characteristics …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to
contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

Pluripotent stem cells are defined by their capacity to differentiate into all three tissue layers
that comprise the body. Chimera formation, generated by stem cell transplantation to the …

Sus scrofa domesticus (pig) has served as a superb large mammalian model for biomedical
studies because of its comparable physiology and organ size to humans. The derivation of …