The human tissue kallikrein gene family was, until recently, thought to consist of only three
genes. Two of these human kallikreins, prostate-specific antigen and human glandular …

Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of
protease genes in the human genome, are secreted serine proteases with diverse …

TRANSCRIPTIONAL activation of target genes represents an important component of the
tumour-suppressor function of p53 and provides a functional link between p53 and various …

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Prostate-specific antigen (PSA) is a widely used marker for the diagnosis and management
of prostate cancer. Minimal enhancer/promoter constructs derived from the 5′ flank of the …

Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases
and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are …

Recent studies on human kallikrein 2 (hK2) have revealed striking similarities and significant
differences with the closely related kallikrein PSA. Both PSA and hK2 are primarily localized …

Prostate-specific antigen (PSA) is a valuable tumor marker for the diagnosis and
management of prostate cancer. The name was intended to underscore the tissue specificity …

Kallikreins are a subgroup of the serine protease enzyme family. Until recently, it was
thought that the human kallikrein gene family contained only three members. In the past 3 …

The traditional human kallikrein gene family consists of three genes, namely KLK1
[encoding human kallikrein 1 (hK1) or pancreatic/renal kallikrein], KLK2 (encoding hK2 …