Evolution of sex differences in lifespan and aging: causes and constraints

AA Maklakov, V Lummaa - BioEssays, 2013 - Wiley Online Library
Why do the two sexes have different lifespans and rates of aging? Two hypotheses based
on asymmetric inheritance of sex chromosomes (“unguarded X”) or mitochondrial genomes …

Population genetics of sexual conflict in the genomic era

JE Mank - Nature Reviews Genetics, 2017 - nature.com
Sexual conflict occurs when selection acts in opposing directions on males and females.
Case studies in both vertebrates and invertebrates indicate that sexual conflict maintains …

Experimental evidence supports a sex-specific selective sieve in mitochondrial genome evolution

P Innocenti, EH Morrow, DK Dowling - Science, 2011 - science.org
Mitochondria are maternally transmitted; hence, their genome can only make a direct and
adaptive response to selection through females, whereas males represent an evolutionary …

[HTML][HTML] Mitochondria, maternal inheritance, and male aging

MF Camus, DJ Clancy, DK Dowling - Current Biology, 2012 - cell.com
The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve,
whereby mutations in mitochondrial DNA can only respond to selection acting directly on …

Genetic architecture of metabolic rate: environment specific epistasis between mitochondrial and nuclear genes in an insect

G Arnqvist, DK Dowling, P Eady, L Gay, T Tregenza… - …, 2010 - academic.oup.com
The extent to which mitochondrial DNA (mtDNA) variation is involved in adaptive
evolutionary change is currently being reevaluated. In particular, emerging evidence …

Dynamic evolution of Geranium mitochondrial genomes through multiple horizontal and intracellular gene transfers

S Park, F Grewe, A Zhu, TA Ruhlman, J Sabir… - New …, 2015 - Wiley Online Library
The exchange of genetic material between cellular organelles through intracellular gene
transfer (IGT) or between species by horizontal gene transfer (HGT) has played an important …

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

MR Patel, GK Miriyala, AJ Littleton, H Yang, K Trinh… - elife, 2016 - elifesciences.org
Due to their strict maternal inheritance in most animals and plants, mitochondrial genomes
are predicted to accumulate mutations that are beneficial or neutral in females but harmful in …

Evolutionary perspectives on the links between mitochondrial genotype and disease phenotype

DK Dowling - Biochimica Et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Background Disorders of the mitochondrial respiratory chain are heterogeneous in their
symptoms and underlying genetics. Simple links between candidate mutations and …

The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance?

M Beekman, DK Dowling… - … Transactions of the …, 2014 - royalsocietypublishing.org
Eukaryotic cells typically contain numerous mitochondria, each with multiple copies of their
own genome, the mtDNA. Uniparental transmission of mitochondria, usually via the mother …

The effect of mitochondrial recombination on fertilization success in blue mussels

G Bramwell, AG Schultz, G Jennings, UN Nini… - Science of the Total …, 2024 - Elsevier
The presence of doubly uniparental inheritance (DUI) in bivalves represents a unique mode
of mitochondrial transmission, whereby paternal (male-transmitted M-type) and maternal …