Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), polycythemia
vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell …

Abstract Background and Aims Somatic mutations in the TET2 gene that lead to clonal
haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice …

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with
varying degrees of dysplasia and peripheral cytopenias. MDS are driven by structural …

Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related
expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging …

Clonal cytopenia of undetermined significance (CCUS) represents a distinct disease entity
characterized by myeloid-related somatic mutations with a variant allele fraction of≥ 2% in …

Clonal hematopoiesis (CH) defines a population of hematopoietic cells with one or more
somatic mutations/copy number alterations that can expand with time and under positive …

Clonal hematopoiesis (CH) mutations are common among individuals without known
hematologic disease. CH mutations have been associated with numerous adverse clinical …