Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for
endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis …

Centronuclear myopathies (CNM) are rare congenital disorders characterized by muscle
weakness and structural defects including fiber hypotrophy and organelle mispositioning …

Distal myopathies are genetic primary muscle disorders with a prominent weakness at onset
in hands and/or feet. The age of onset (from early childhood to adulthood), the distribution of …

Clathrin plaques are stable features of the plasma membrane observed in several cell types.
They are abundant in muscle, where they localize at costameres that link the contractile …

Abstract Dynamin 2 (DNM2) belongs to a family of large GTPases that are well known for
mediating membrane fission by oligomerizing at the neck of membrane invaginations …

The endosomal system plays an essential role in cell homeostasis by controlling cellular
signaling, nutrient sensing, cell polarity and cell migration. However, its place in the …

Rapid advances in allele‐specific silencing by RNA interference established a strategy of
choice to cure dominant inherited diseases by targeting mutant alleles. We used this …

Diabetes is associated with an increase in skeletal fragility and risk of fracture. However, the
underlying mechanism for the same is not well understood. Specifically, the results from …

Centronuclear myopathy (CNM) is a congenital myopathy characterised by centralised
nuclei in skeletal myofibers. T-tubules, sarcolemmal invaginations required for excitation …

Abstract Dynamin 2 (DNM2) is a GTP-binding protein that controls endocytic vesicle scission
and defines a whole class of dynamin-dependent endocytosis, including clathrin-mediated …