Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

The restrictive nature of the blood–brain barrier (BBB) creates a major challenge for brain
drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular …

Zn2+ deficiency in the human population is frequent in underdeveloped countries.
Worldwide, approximatively 2 billion people consume Zn2+-deficient diets, accounting for 1 …

In addition to their primary roles in hemostasis and thrombosis, platelets participate in many
other physiological and pathological processes, including, but not limited to inflammation …

Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder
characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion of …

Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α-and
δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the …

Gray platelet syndrome (GPS) is a rare recessive disorder caused by biallelic variants in
NBEAL2 and characterized by bleeding symptoms, the absence of platelet α-granules …

Much interest surrounds the receptors α2β1 and glycoprotein VI (GPVI) whose synchronized
action mediates the attachment and activation of platelets on collagen, essential for …

Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in
thrombocytopathies variously characterized by defects of their adhesive and procoagulant …

Gray platelet syndrome (GPS) is an autosomal recessive bleeding disorder characterized by
a lack of α-granules in platelets and progressive myelofibrosis. Rare loss-of-function variants …