Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Since its first splash 30 years ago, the use of the zebrafish model has been extended from a
tool for genetic dissection of early vertebrate development to the functional interrogation of …

The development of facile forward and reverse genetic approaches has propelled the
deconvolution of gene function in biology. While the origins of these techniques reside in the …

Due to the clear separation of innate immunity from adaptive responses, the externally
developing zebrafish embryo represents a useful in vivo model for identification of innate …

All multicellular organisms protect themselves against pathogens using sophisticated
immune defenses. Functionally interconnected humoral and cellular facilities maintain …

The evolutionary emergence of vertebrates was accompanied by the invention of adaptive
immunity. This is characterized by extraordinarily diverse repertoires of somatically …

Over the past two decades, studies have demonstrated that several features of T-cell and
thymic development are conserved from teleosts to mammals. In particular, works using …

T-cell neoplasias are common in pediatric oncology, and include acute lymphoblastic
leukemia (T-ALL) and lymphoblastic lymphoma (T-LBL). These cancers have worse …

Chemokines and chemokine receptors are key evolutionary innovations of vertebrates. They
are involved in morphogenetic processes and play an important role in the immune system …

Exploitation of the zebrafish model in hematology research has surged in recent years,
becoming one of the most useful and tractable systems for understanding regulation of …