Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA consortium findings

FT Crews, DL Robinson, LJ Chandler… - Alcoholism: clinical …, 2019 - Wiley Online Library
The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on
the impact of adolescent binge drinking on brain development, particularly on effects that …

Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis

R Kim, KL Healey, MT Sepulveda-Orengo… - Progress in Neuro …, 2018 - Elsevier
Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …

Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences

HHA Thorpe, S Hamidullah, BW Jenkins… - Pharmacology & …, 2020 - Elsevier
Adolescence is the transitional period between childhood and adulthood, during which
extensive brain development occurs. Since this period also overlaps with the initiation of …

Targeting persistent changes in neuroimmune and epigenetic signaling in adolescent drinking to treat alcohol use disorder in adulthood

FT Crews, LG Coleman, VA Macht, RP Vetreno - Pharmacological Reviews, 2023 - ASPET
Studies universally find early age of drinking onset is linked to lifelong risks of alcohol
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …

[HTML][HTML] Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty …

SN Hellberg, TI Russell, MJF Robinson - Cognitive, Affective, & Behavioral …, 2019 - Springer
Gambling disorder is an impairing condition confounded by psychiatric co-morbidity,
particularly with substance use and anxiety disorders. Yet, our knowledge of the …

Under the influence: Effects of adolescent ethanol exposure and anxiety on motivation for uncertain gambling-like cues in male and female rats

SN Hellberg, JD Levit, MJF Robinson - Behavioural Brain Research, 2018 - Elsevier
Gambling disorder (GD) frequently co-occurs with alcohol use and anxiety disorders,
suggesting possible shared mechanisms. Recent research suggests reward uncertainty may …

The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents

DL Robinson, LR Amodeo, LJ Chandler… - International review of …, 2021 - Elsevier
Alcohol drinking is often initiated during adolescence, and this frequently escalates to binge
drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical …

Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

CA Dannenhoffer, A Gómez‐A… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Binge alcohol exposure during adolescence results in long‐lasting alterations
in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in …

[HTML][HTML] A mechanical task for measuring sign-and goal-tracking in humans: a proof-of-concept study

LM Cope, A Gheidi, ME Martz, ER Duval… - Behavioural brain …, 2023 - Elsevier
Cue-based associative learning (ie, Pavlovian conditioning) is a foundational component of
behavior in almost all forms of animal life and may provide insight into individual differences …

Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations

U Gyawali, DA Martin, F Sun, Y Li, D Calu - Elife, 2023 - elifesciences.org
Midbrain and striatal dopamine signals have been extremely well characterized over the
past several decades, yet novel dopamine signals and functions in reward learning and …