Mitochondrial DNA (mtDNA) encodes proteins and RNAs that are essential for mitochondrial
function and cellular homeostasis, and participates in important processes of cellular …

In the last decades, studies about ageing have become more essential as our population
grows older. The incidence of age-related diseases increases, which pose challenges both …

Tumor suppressor p53 plays a pivotal role in orchestrating mitochondrial remodeling by
regulating their content, fusion/fission processes, and intracellular signaling molecules that …

Our study focused on the relationship between amyloid β 1–42 (Aβ), sphingosine kinases
(SphKs) and mitochondrial sirtuins in regulating cell fate. SphK1 is a key enzyme involved in …

In colorectal cancer, no study has been carried out discovering the relationship among p53,
mitochondrial transcription factor A (TFAM) expression and change of mitochondrial DNA …

Data for p53 mutation in prostate cancer in The Cancer Genome Atlas database revealed
that> 85% of p53 mutations occurred in the p53 DNA binding domain. These mutations not …

Combination antiretroviral therapy (cART) has been hugely successful in reducing the
mortality associated with human immunodeficiency virus (HIV) infection, resulting in a …

Somatic mutations affecting the mitochondrial DNA (mtDNA) have been frequently observed
in human cancers and proposed as important oncological biomarkers. However, the clinical …

The rise in obesity and diabetes in various countries have reached epidemic proportions [1]
with the inability of the brain to regulate body weight and energy balance in the early part of …

Nutritional diets are essential to prevent nonalcoholic fatty liver disease (NAFLD) in the
global obesity and diabetes epidemic. The ingestion of palmitic acid-rich diets induces …