Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …

Transcription factor EB (TFEB) represents an emerging player in cancer biology. Together
with microphthalmia‐associated transcription factor, transcription factor E3 and transcription …

The cellular activation of the NLRP3 inflammasome is spatiotemporally orchestrated by
various organelles, but whether lysosomes contribute to this process remains unclear. Here …

Biomaterials are one of efficient treatment options for tissue defects in regenerative
medicine. Compared to synthetic materials which tend to induce chronic inflammatory …

Macrophages are heterogeneous and plastic, and play several diverse functions in immune
responses. Emerging data provide evidence of multiple roles for metabolic pathways in the …

Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB)
and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and …

Lysosomes are involved in nutrient sensing via the mechanistic target of rapamycin complex
1 (mTORC1). mTORC1 is tethered to lysosomes by the Ragulator complex, a …

Our understanding of lysosomes has undergone a significant transformation in recent years,
from the view that they are static organelles primarily responsible for the disposal and …

Chemotherapy resistance remains a significant obstacle that limits the long-term efficacy of
cancer therapy, necessitating further investigations into the underlying mechanisms. Here …

Beta-coronaviruses have emerged as a severe threat to global health. Undercovering the
interplay between host and beta-coronaviruses is essential for understanding disease …