The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

During angiogenesis, new vessels emerge from existing endothelial lined vessels to
promote the degradation of the vascular basement membrane and remodel the extracellular …

Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …

Abstract Background Tumor-associated macrophages (TAMs) are major components of
tumor microenvironment that frequently associated with tumor metastasis in human cancers …

Background Tumor microenvironment (TME) is a complex environment containing tumor
cells, tumor-associated macrophages (TAMs), interstitial cells, and non-cellular components …

Abstract Background Tumor-associated macrophages (TAMs) in the tumor
microenvironment influence tumor initiation, invasion and metastasis. Several studies have …

Cancer immunotherapy has achieved tremendous successful clinical results and obtained
historic victories in tumor treatments. However, great limitations associated with feeble …

In industrialized countries, cancer is the second leading cause of death after cardiovascular
disease. Most cancer patients die because of metastases, which consist of the self …

Previous evidence has highlighted M2 macrophage regulation of cancer cells via exosome
shuttling of microRNAs (miRNAs or miRs). The current study set out to explore the possible …