The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

This review focuses on recent advances in catalytic metal-free transfer hydrogenations. In
recent years dihydropyridines have been widely used as reducing agents in organocatalytic …

Direct asymmetric reductive amination is one of the most efficient methods for the
construction of chiral amines, in which the scope of the applicable amine coupling partners …

Conspectus The asymmetric reduction of ketimines is an important method for the
preparation of amines in optically pure form. Inspired by the biological system using NAD (P) …

The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by
an iridium complex for the preparation of enantiomerically pure β‐arylamines is described …

Asymmetric reductive amination (ARA) affords synthetically valuable chiral amines
straightforwardly. This chapter reviews the recent advances made in the area, focusing on …

Reductive amination is considered as the most popular and established approaches which
provide rapid access to different types of amines, important intermediates for the production …

This review summarizes the recent progress of organocatalytic and biocatalytic asymmetric
reductive amination (ARA), a challenging but important topic for drug discovery and the …

Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-
ones, was developed using chiral phosphoric acid as catalyst and a Hantzsch ester as the …