Optical genome mapping for cytogenetic diagnostics in AML
Simple Summary Today, the classification of acute myeloid leukemia is mainly based on
genetic aberrations found in leukemic cells. Classifying this disease is necessary for exact …
genetic aberrations found in leukemic cells. Classifying this disease is necessary for exact …
The role of next-generation sequencing in acute myeloid leukemia
M Llop, C Sargas, E Barragán - Current Opinion in Oncology, 2022 - journals.lww.com
NGS has proven to be a useful approach for the analysis of genomic alterations in patients
with AML, which aids patient management. Current research is being directed at reducing …
with AML, which aids patient management. Current research is being directed at reducing …
Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be
comprehensively defined. Here, we present the spectrum of genomic alterations in 136 …
comprehensively defined. Here, we present the spectrum of genomic alterations in 136 …
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients
Genetic instability is a major concern for successful application of stem cells in regenerative
medicine. However, the mutational consequences of the most applied stem cell therapy in …
medicine. However, the mutational consequences of the most applied stem cell therapy in …
Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors
UBTF tandem duplications (UBTF-TDs) have recently emerged as a recurrent alteration in
pediatric and adult acute myeloid leukemia (AML). UBTF-TD leukemias are characterized by …
pediatric and adult acute myeloid leukemia (AML). UBTF-TD leukemias are characterized by …
UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia
N Duployez, L Vasseur, R Kim, L Largeaud, M Passet… - Leukemia, 2023 - nature.com
Tandem duplications (TDs) of the UBTF gene have been recently described as a recurrent
alteration in pediatric acute myeloid leukemia (AML). Here, by screening 1946 newly …
alteration in pediatric acute myeloid leukemia (AML). Here, by screening 1946 newly …
UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment
L Bastian, AM Hartmann, T Beder, S Hänzelmann… - Leukemia, 2022 - nature.com
Genomic aberrations—gene fusions in the majority of cases—and corresponding
transcriptional regulations define an increasingly complex landscape of molecular subtypes …
transcriptional regulations define an increasingly complex landscape of molecular subtypes …
Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL
M Passet, R Kim, S Gachet, F Sigaux… - Blood, The Journal …, 2022 - ashpublications.org
Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults
remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA …
remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA …
Convergent epigenetic evolution drives relapse in acute myeloid leukemia
Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment
refractory. We analyzed previously published AML relapse cohorts and found that 40% of …
refractory. We analyzed previously published AML relapse cohorts and found that 40% of …
IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation
Rare preleukemic hematopoietic stem cells (pHSC) harboring only the initiating mutations
can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the …
can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the …