Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

BACKGROUND The ultimate goal of synthetic chemistry is the efficient assembly of
molecules from readily available starting materials with minimal waste generation. The …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

As two coexisting and fast-growing research fields in modern synthetic chemistry, the
merging of organocatalysis and C–H bond functionalization is well foreseeable, and the joint …

A direct enantioselective acylation of α-amino C (sp3)–H bonds with carboxylic acids has
been achieved via the merger of transition metal and photoredox catalysis. This …

Enantioselective C–H functionalization is a powerful tool for synthesizing chiral molecules.
In the past few years, the combination of high-valent group 9 metals with achiral Cpx ligands …

Desymmetrization is an essential method for the synthesis of chiral compounds, particularly
chiral biaryls. We have developed an enantioselective synthesis of axially chiral biaryls by …

Methods that enable the practical and selective functionalization of traditionally unreactive
aliphatic C–H bonds have synthetic applications in fields ranging from drug discovery to …