688 Hypertension October 2017 clinical patterns of HIRD susceptibility schematically
illustrated in Figure 1 with respect to the BP threshold for HIRD and the slopes of the …

The spontaneously hypertensive rat (SHR) is one of the major models of hypertension. This
article describes the current state of knowledge about the mechanism behind kidney …

Monocyte/macrophage recruitment is closely associated with the degree of hypertensive
renal injury. We investigated the direct role of macrophages using liposome-encapsulated …

Background Age, CKD risk factors, and kidney function are associated with larger
glomerular volume and a higher percentage of globally sclerotic glomeruli. Knowledge of …

The activated renin–angiotensin–aldosterone system increases blood pressure and
intracellular signals, thus leading to cardiac fibrosis. Whether increased blood pressure or …

BACKGROUND Hypertension and metabolic syndrome (MetS) are associated with
increased sympathetic activation possibly contributing to the progression of renal damage …

Focal segmental glomerulosclerosis (FSGS) is a kidney disease with progressive glomerular
scarring and a clinical presentation of nephrotic syndrome. FSGS is a common primary …

The underlying mechanisms by which renal denervation (RD) decreases blood pressure
(BP) remain incompletely understood. In this study, we investigated the effects of ischemic …

Vascular injury and remodeling are common pathological sequelae of hypertension.
Previous studies have suggested that the renin-angiotensin system acting through the type 1 …

The present study examined the extent to which leukocyte infiltration into the kidneys in Ang
II (angiotensin II)-induced hypertension is determined by elevation of renal perfusion …