RAS proteins require membrane association for their biologic activity, making this
association a logical target for anti-RAS therapeutics. Lipid modification of RAS proteins by a …

Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

Cholesterol is an essential component of metazoan cellular membranes and it helps to
maintain the structural integrity and fluidity of the plasma membrane. Here, we developed a …

Plasma membrane depolarization can trigger cell proliferation, but how membrane potential
influences mitogenic signaling is uncertain. Here, we show that plasma membrane …

Ras proteins assemble into transient nanoclusters on the plasma membrane. Nanoclusters
are the sites of Ras effector recruitment and activation and are therefore essential for signal …

KRas is a major proto-oncogene product whose signaling activity depends on its level of
enrichment on the plasma membrane (PM). This PM localization relies on posttranslational …

The TMEM16 family of membrane proteins, also known as anoctamins, plays key roles in a
variety of physiological functions that range from ion transport to phospholipid scrambling …

Lipid-anchored Ras GTPases form transient, spatially segregated nanoclusters on the
plasma membrane that are essential for high-fidelity signal transmission. The lipid …

Aberrant signaling by oncogenic mutant rat sarcoma (Ras) proteins occurs in∼ 15% of all
human tumors, yet direct inhibition of Ras by small molecules has remained elusive …

The molecular mechanisms whereby caveolae exert control over cellular signaling have to
date remained elusive. We have therefore explored the role caveolae play in modulating …