[HTML][HTML] How to fail with paired VNS therapy

SA Hays, RL Rennaker II, MP Kilgard - Brain stimulation, 2023 - Elsevier
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic
therapy. In particular, the delivery of VNS paired with training to promote neural changes has …

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial

J Dawson, CY Liu, GE Francisco, SC Cramer, SL Wolf… - The lancet, 2021 - thelancet.com
Background Long-term loss of arm function after ischaemic stroke is common and might be
improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine …

Targeting the autonomic nervous system for risk stratification, outcome prediction and neuromodulation in ischemic stroke

A Carandina, G Lazzeri, D Villa, A Di Fonzo… - International Journal of …, 2021 - mdpi.com
Ischemic stroke is a worldwide major cause of mortality and disability and has high costs in
terms of health-related quality of life and expectancy as well as of social healthcare …

Transcutaneous auricular vagus nerve stimulation promotes white matter repair and improves dysphagia symptoms in cerebral ischemia model rats

L Long, Q Zang, G Jia, M Fan, L Zhang, Y Qi… - Frontiers in Behavioral …, 2022 - frontiersin.org
Background Clinical and animal studies have shown that transcutaneous auricular vagus
nerve stimulation (ta-VNS) exerts neuroprotection following cerebral ischemia. Studies have …

[HTML][HTML] Characterization of vagus nerve stimulation-induced pupillary responses in epileptic patients

S Vespa, L Stumpp, G Liberati, J Delbeke, A Nonclercq… - Brain stimulation, 2022 - Elsevier
Background Modulation of the locus coeruleus (LC)-noradrenergic system is a key
mechanism of vagus nerve stimulation (VNS). Activation of the LC produces pupil dilation …

Vagus nerve stimulation enhances fear extinction as an inverted-U function of stimulation intensity

RR Souza, NM Robertson, CK McIntyre… - Experimental …, 2021 - Elsevier
Studies in rodents indicate that pairing vagus nerve stimulation (VNS) with extinction training
enhances fear extinction. However, the role of stimulation parameters on the effects of VNS …

Effects of non‐invasive vagus nerve stimulation on cognitive and autonomic correlates of perseverative cognition

S De Smet, C Ottaviani, B Verkuil, M Kappen… - …, 2023 - Wiley Online Library
Perseverative cognitions can provoke psychophysiological stress in the absence of an
actual stressor and are considered important transdiagnostic vulnerability factors for several …

Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery

KM Malley, AD Ruiz, MJ Darrow, T Danaphongse… - Scientific Reports, 2024 - nature.com
Impairments in somatosensory function are a common and often debilitating consequence of
neurological injury, with few effective interventions. Building on success in rehabilitation for …

High intensity VNS disrupts VNS-mediated plasticity in motor cortex

RA Morrison, TT Danaphongse, ST Abe, ME Stevens… - Brain research, 2021 - Elsevier
Vagus nerve stimulation (VNS) paired with motor rehabilitation enhances recovery of
function after neurological injury in rats and humans. This effect is ascribed to VNS …

Vagus nerve stimulation as a potential adjuvant to rehabilitation for post-stroke motor speech disorders

RA Morrison, SA Hays, MP Kilgard - Frontiers in Neuroscience, 2021 - frontiersin.org
Stroke often leaves lasting impairments affecting orofacial function. While speech therapy is
able to enhance function after stroke, many patients see only modest improvements after …