Heterogeneity of Human CD4+ T Cells Against Microbes
F Sallusto - Annual review of immunology, 2016 - annualreviews.org
CD4+ T helper (Th) cells play a central role in the adaptive immune response by providing
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …
T and B‐cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity
S Preite, J Gomez‐Rodriguez, JL Cannons… - Immunological …, 2019 - Wiley Online Library
Abstract Phosphatidylinositol 3 kinases (PI3K) are a family of lipid kinases that are activated
by a variety of cell‐surface receptors, and regulate a wide range of downstream readouts …
by a variety of cell‐surface receptors, and regulate a wide range of downstream readouts …
Acetate differentially regulates IgA reactivity to commensal bacteria
T Takeuchi, E Miyauchi, T Kanaya, T Kato, Y Nakanishi… - Nature, 2021 - nature.com
The balance between bacterial colonization and its containment in the intestine is
indispensable for the symbiotic relationship between humans and their bacteria. One …
indispensable for the symbiotic relationship between humans and their bacteria. One …
In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells
T follicular helper (Tfh) cells provide signals to initiate and maintain the germinal center (GC)
reaction and are crucial for the generation of robust, long-lived antibody responses, but how …
reaction and are crucial for the generation of robust, long-lived antibody responses, but how …
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity
Gain-of-function mutations in the gene encoding the phosphatidylinositol-3-OH kinase
catalytic subunit p110δ (PI3Kδ) result in a human primary immunodeficiency characterized …
catalytic subunit p110δ (PI3Kδ) result in a human primary immunodeficiency characterized …
Regulatory T cells as potential targets for HIV cure research
AJ Kleinman, R Sivanandham, I Pandrea… - Frontiers in …, 2018 - frontiersin.org
T regulatory cells (Tregs) are a key component of the immune system, which maintain a
delicate balance between overactive responses and immunosuppression. As such, Treg …
delicate balance between overactive responses and immunosuppression. As such, Treg …
[HTML][HTML] IL-17–producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice
Abstract Follicular Th (Tfh) cells are key CD4+ Th cells involved in regulating B cell
differentiation in the germinal center. Mice with conditional KO (CKO) of B lymphocyte …
differentiation in the germinal center. Mice with conditional KO (CKO) of B lymphocyte …
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy
Background Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells
including increased expression of co-inhibitory receptors (IRs) and skewing toward a T …
including increased expression of co-inhibitory receptors (IRs) and skewing toward a T …
PI3K orchestrates T follicular helper cell differentiation in a context dependent manner: implications for autoimmunity
T follicular helper (Tfh) cells are a specialized population of CD4+ T cells that provide help to
B cells for the formation and maintenance germinal centers, and the production of high …
B cells for the formation and maintenance germinal centers, and the production of high …
Control of the germinal center by follicular regulatory T cells during infection
Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact
adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their …
adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their …