The facet joint is a crucial anatomic region of the spine owing to its biomechanical role in
facilitating articulation of the vertebrae of the spinal column. It is a diarthrodial joint with …

Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin,
there has been an increasing interest in the study of undifferentiated progenitors that have …

To withstand physiological loading over a lifetime, human synovial joints are covered and
protected by articular cartilage, a layer of low-friction, load-bearing tissue. The unique …

This paper reports the development of a platform technology for measuring platelet function
and aggregation based on localized strain rate micro-gradients. Recent experimental …

Objective Hyaline cartilage degenerative pathologies induce morphologic and
biomechanical changes resulting in cartilage tissue damage. In pursuit of therapeutic …

Mechanical forces are critical components of the cellular microenvironment and play a
pivotal role in driving cellular processes in vivo. Dissecting cellular responses to mechanical …

With continued development and improvement of tissue engineering therapies for small
articular lesions, increased attention is being focused on the challenge of engineering …

Objective To investigate the combination of mild mechanical stimuli and a disease modifying
osteoarthritis drug (DMOAD) in inflammatory activated chondrocytes and to study the …

Background Characterized chondrocyte implantation results in superior structural repair
compared with microfracture, but may be associated with a slower recovery of physical …

Tooth loss often results in alveolar bone resorption because of lack of mechanical
stimulation. Thus, the mechanism of mechanical loading on stem cell osteogenesis is crucial …