The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Altered metabolism, associated with acidification of the extracellular milieu, is one of the
major features of cancer. As pH regulation is crucial for the maintenance of all biological …

Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms
are not completely understood. Using a phosphoproteomics screen, we now show that …

Mitochondria must buffer the risk of proteotoxic stress to preserve bioenergetics, but the role
of these mechanisms in disease is poorly understood. Using a proteomics screen, we now …

Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current
therapies are not curative, and patients' outcomes remain poor with an overall survival of …

Hepatocellular carcinoma (HCC) is refractory to chemotherapies, necessitating novel
effective agents. The lysosome inhibitor Bafilomycin A1 (BafA1) at high concentrations …

The control of the intracellular pH is vital for the survival of all organisms. Membrane
transporters, both at the plasma and intracellular membranes, are key players in maintaining …

Ion channels provide the basis for the nervous system's intrinsic electrical activity. Neuronal
excitability is a characteristic property of neurons and is critical for all functions of the …

Tailored nanocarriers have gained huge research focus for brain drug delivery, aimed at
combating several neuro-oncological conditions, such as the glioblastoma multiforme …

OBJECTIVE The (pro) renin receptor (PRR) plays an essential role in the early development
of the central nervous system by activating the Wnt/β-catenin signaling pathway. The authors …