The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-
associated system (Cas) gene-editing system represents a promising tool for genome …

Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

Genome editing technology has emerged as a potential therapeutic tool for treating
incurable diseases. In particular, the discovery of clustered regularly interspaced short …

Three-dimensional (3D) bioprinting is an emerging technology based on 3D digital imaging
technology and multi-level continuous printing. The precise positioning of biological …

Osteoporosis (OP) affects millions worldwide but currently cannot be cured. Suppressing the
level of miR-214 in osteoclasts by the anti-miRNA oligonucleotide (AMO) anti-miR-214 …

Due to the critical limitations of conventional antitumor agents, great efforts have been made
to develop advanced drug delivery systems to enhance the therapeutic outcomes of …

BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early
osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited …

The promise of cell therapy has been augmented by introducing biomaterials, where
intricate scaffold shapes are fabricated to accommodate the cells within. In this review, we …

Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main
pathological change, is the major source of pain and disability worldwide. Despite current …

Exosomes, remarkable extracellular vesicles, have emerged as an advanced frontier in
intercellular communication. This remarkable capacity positions them as promising …