Computational prediction of the phenotypic propensities of noncoding single nucleotide
variants typically combines annotation of genomic, functional and evolutionary attributes into …

The nucleotide salvage pathway is used to recycle degraded nucleotides (purines and
pyrimidines); one of the enzymes that helps to recycle purines is hypoxanthine guanine …

Traditional informatics in comparative genomics work only with static representations of
biomolecules (ie, sequence and structure), thereby ignoring the molecular dynamics (MD) of …

A long-held presupposition in the field of bioinformatics holds that genetic, and now even
epigenetic 'information'can be abstracted from the physicochemical details of the …

The aim of our study was to set up a panel for targeted sequencing of chemoresistance
genes and the main transcription factors driving their expression and to evaluate their …

ABSTRACT Mutations in the Peripheral Myelin Protein 22 (PMP22) leads to Charcot Marie
Tooth type 1A (CMT1A, a subtype of CMT1) disease which is the most common inherited …

Pharmacogenomics holds the promise of personalized drug efficacy optimization and drug
toxicity minimization. Much of the research conducted to date, however, suffers from an …

Artificial Intelligence-driven Prediction Revealed CFTR Associated With Therapy Outcome Of
Breast Cancer: A Feasibility Study Page 1 1 Oncology , DOI: 10.1159/000540395 Received …

Myelin protein zero (MPZ) gene encodes MPZ protein is a vital component of the myelin
sheath. Mutationsassociated with MPZ gene leads to severe de-hypomyelination Dejerine …

Next‐generation sequencing technology has afforded the discovery of many novel variants
that are of significance to inheritable pharmacogenomics (PGx) traits but a large proportion …