L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

WITH THE ESSENTIALLY simultaneous cloning in 1989 of the selectins (then called ELAM-
1, GMP-140/PADGEM, and LECAM-l/LAM-1; now called E-selectin, P-selectin, and L …

Intramammary infections of dairy cows with Gram-positive bacteria such as Staphylococcus
aureus (major cause of mastitis) have received a lot of attention because of their major …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

The selectin family of adhesion molecules mediates the initial attachment of leukocytes to
venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury …

Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase and the receptor
for the SARS and NL63 coronaviruses (CoV). Loss of ACE2 function is implicated in severe …

Many membrane-bound proteins, including cytokines, receptors, and growth factors, are
proteolytically cleaved to release a soluble form of their extracellular domain. The tumor …

A diverse range of membrane proteins of Type I or Type II topology also occur as a
circulating, soluble form. These soluble forms are often derived from the membrane form by …

Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in
fertilization and in the processing of the ectodomains of proteins such as tumor necrosis …

L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating
leukocytes, including neutrophils. Engagement of L-selectin with endothelial-derived ligands …