Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s) …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Ester bond hydrolysis of membrane phospholipids by Phospholipase A2 and consequent
release of fatty acids are the initiating steps of inflammation. It is proposed in this study that …

The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and
inactive, are a central component in envenoming. These are responsible for disrupting the …

Envenomations by Bothrops asper are often associated with complex and severe local
pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and …

Envenomation via snakebites is an important public health problem in many tropical and
subtropical countries that, in addition to mortality, can result in permanent sequelae as a …

Suramin, a synthetic polysulfonated compound, developed initially for the treatment of
African trypanosomiasis and onchocerciasis, is currently used for the treatment of several …

Myotoxins play a major role in the pathogenesis of the envenomations caused by snake
bites in large parts of the world where this is a very relevant public health problem. We show …

Myotoxin-II, a phospholipase A 2 (PLA 2)-like protein found in Bothrops asper venom,
causes rapid necrosis of muscle fibers in spite of lacking enzymatic activity. This toxic action …