Cytoplasmic dynein-1 is a minus-end-directed microtubule motor that transports a variety of
cargoes including early endosomes, late endosomes and other organelles. In many cell …

Nuclear movement within a cell occurs in a variety of eukaryotic organisms including yeasts
and filamentous fungi. Fungal molecular genetic studies identified the minus-end-directed …

Hyphae represent a hallmark structure of multicellular fungi. The evolutionary origins of
hyphae and of the underlying genes are, however, hardly known. By systematically …

Deficiency of the LIS1 protein causes lissencephaly, a brain developmental disorder.
Although LIS1 binds the microtubule motor cytoplasmic dynein and has been linked to …

Filamentous fungi have proven to be a better-suited model system than unicellular yeasts in
analyses of cellular processes such as polarized growth, exocytosis, endocytosis, and …

Filamentous fungi have been used for studying long-distance transport of cargoes driven by
cytoplasmic dynein. Aspergillus nidulans is a well-established genetic model organism used …

Impairment of the Neurospora crassa COT-1 kinase results in defects in hyphal polarity.
Some of these effects are partially suppressed by inactivation of gul-1 (encoding an mRNA …

The cytoskeleton provides structure, shape and movement to various cells. Microtubules
(MTs) are tubular structures made of α and β-tubulin heterodimers organized in 13 …

Cytoplasmic dynein-mediated intracellular transport needs the multi-component dynactin
complex for cargo binding and motor activation. However, cellular factors involved in …

El crecimiento polarizado es esencial para el desarrollo de los organismos y puede
apreciarse en las raíces de las plantas, en la extensión de las neuronas y hasta en las hifas …