Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Chiral transition metal catalysts represent a powerful and economic tool for implementing
stereocenters in organic synthesis, with the metal center providing a strong chemical …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

Rhodium (Rh) acylnitrene complexes are widely implicated in catalytic C–H amidation
reactions but have eluded isolation and structural characterization. To overcome this …

Abstract Transition-metal-catalysed, non-enzymatic transformations of C–H and C= C bonds
to C–N bonds through nitrene transfer (NT) are powerful synthetic tools to prepare valuable …

Conspectus Catalytic reactions that construct carbon–nitrogen bonds are one of central
themes in both synthetic and medicinal chemistry since the obtainable nitrogen-containing …

The magic methyl effect is well acknowledged in medicinal chemistry, but despite its
significance, accessing such analogues via derivatization at a late stage remains a pivotal …

A nickel-catalyzed N–N cross-coupling for the synthesis of hydrazides is reported. O-
Benzoylated hydroxamates were efficiently coupled with a broad range of aryl and aliphatic …

Hydroamination facilitated by metal hydride catalysis is an appealing synthetic approach to
access valuable nitrogen-containing compounds from readily available unsaturated …

Asymmetric, radical C–H functionalizations are rare but powerful tools for solving modern
synthetic challenges. Specifically, the enantio-and regioselective C–H amination of alcohols …