In the past two decades, record-breaking heatwaves have caused an increasing number of
heat-related deaths, including heatstroke, globally. Heatstroke is a heat illness characterized …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …

Rhabdomyolysis is a serious and potentially life threatening condition. Although consensus
criteria for rhabdomyolysis is lacking, a reasonable definition is elevation of serum creatine …

Malignant hyperthermia is defined in the International Classification of Diseases as a
progressive life‐threatening hyperthermic reaction occurring during general anaesthesia …

Rhabdomyolysis is characterized by severe acute muscle injury resulting in muscle pain,
weakness, and/or swelling with release of myofiber contents into the bloodstream …

Over the past decade there have been major advances in defining the genetic basis of the
majority of congenital myopathy subtypes. However the relationship between each …

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle triggered by
volatile anesthetics or succinylcholine. It manifests as a potentially lethal hypermetabolic …

It is 30 yr since the British Journal of Anaesthesia published the first consensus protocol for
the laboratory diagnosis of malignant hyperthermia susceptibility from the European …

Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …